Does coronary calcium score add value to European SCORE in an asymptomatic population?

Abstract Background Despite being a controversial subject, multiple guidelines mention the use of Coronary Artery Calcification (CAC) scoring in cardiovascular risk prediction asymptomatic population. Adding CAC score to European SCORE (Systematic Risk Evaluation) may improve MACE (Major Adverse Cardiovascular Events), providing better stratification. Purpose Our study aims evaluate impact severity compared with and estimate additional value stratification low- region Methods results The consisted prospective registry 1110 individuals free known coronary heart disease, enrolled from GENEMACOR referred for computed tomography assessment. mean age was 51.6±8.2 years, 74.1% were male. This population followed 5.2±3.3 years primary endpoint all-cause events. extent differs significantly between men women same group. Therefore, distribution by gender done using Hoff's nomogram (a). According this nomogram, 3 categories created: low (0≤CAC<100 P<50); moderate (100≤CAC<400 or P50–75) high (CAC≥400 P>75). Through Cox regression occurrence, does not remain equation, higher level presented significant occurrence an HR 7.943 (95% CI 2.948 – 21.401; p<0.0001). Using C-index, superior (0.729 vs 0.615; increased alone (AUC 0.77 p=0.003). Conclusion point importance inclusion prevention clinical practice could have prognostic on prediction. Larger multicenter cohorts longer follow-up should reproduce validate these findings. Funding Acknowledgement Type funding sources: None. Table 1